Reaktion #46215

Reaktionsgleichung

(2,3-dihydro-benzo[1,4]dioxin-6-yl)methanol

SOCl2

→

6-chloromethyl-2,3-dihydro-benzo[1,4]dioxine

Ausbeute 88.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic layer was separated
2. 2
   Extraktionthe aqueous phase was extracted with dichloromethane (50 mL×3)
3. 3
   WaschenThe combined organic layers were washed with NaHCO3 (sat solution), water and brine
4. 4
   Trocknendried over Na2SO4
5. 5
   Einengenconcentrated to dryness

Vorschrift

A mixture of (2,3-dihydro-benzo[1,4]dioxin-6-yl)methanol (10.6 g) in SOCl2 (10 mL) was stirred at room temperature for 10 min and then poured into ice-water. The organic layer was separated and the aqueous phase was extracted with dichloromethane (50 mL×3). The combined organic layers were washed with NaHCO3 (sat solution), water and brine, dried over Na2SO4 and concentrated to dryness to obtain 6-chloromethyl-2,3-dihydro-benzo[1,4]dioxine (12 g, 88% over two steps), which was used directly in next step.

Quelle