Reaktion #462067

Reaktionsgleichung

sodium dithionite

ethyl 2-cyanoglyoxylate-2-oxime

→

title compound

Ausbeute 37.4%

Ethyl 2-amino-2-cyanoacetate

Ausbeute 37.4%

Lösungsmittel

H2O

sodium hydrogen carbonate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionsaturated with NaCl and extracted 5 times with dichloromethane
2. 2
   TrocknenAfter drying with calcium chloride
3. 3
   Einengenthe organic phase is concentrated

Vorschrift

119 g of sodium dithionite are added in portions (15 min) at room temperature to 35 g (0.246 mol) of ethyl 2-cyanoglyoxylate-2-oxime in 350 ml of H2O and 280 ml of saturated sodium hydrogen carbonate solution. The mixture is then warmed at 35° C. for 1 hour; it is then saturated with NaCl and extracted 5 times with dichloromethane. After drying with calcium chloride, the organic phase is concentrated. 11.8 g of the title compound are obtained as an oil.

Quelle