Reaktion #46167

Reaktionsgleichung

2-Bromo-3-phenyl-6-(3-phenylpropoxy)indene-1-one

Copper (I) cyanide

ammonium chloride

→

title compound

Ausbeute 83.3%

1-oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

Ausbeute 83.3%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled
2. 2
   ExtraktionThe organic layer was extracted with ethyl acetate
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated
5. 5
   Sonstigethe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3)

Vorschrift

2-Bromo-3-phenyl-6-(3-phenylpropoxy)indene-1-one (1.0 g, 2.3 mmol) was dissolved in N,N-dimethylformamide (10 ml). Copper (I) cyanide (617 mg, 6.9 mmol) was added thereto and the mixture was stirred for 3 hours at 150° C. The mixture was cooled, and saturated ammonium chloride was added thereto. The organic layer was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3) to obtain the title compound (700 mg, yield 80%) as a red solid.

Quelle