Reaktion #46157

Reaktionsgleichung

Piperonyl alcohol

Triethylamine

thionyl chloride

→

5-chloromethyl benzo[1,3]dioxol

Ausbeute 100.0%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe reaction mixture was extracted with sodium bicarbonate and ethyl acetate
2. 2
   Sonstigethe organic layer was separated
3. 3
   Trocknendried over anhydrous magnesium sulfate

Vorschrift

Piperonyl alcohol (10 g, 65.7 mmol) was dissolved in benzene. Triethylamine (11 ml, 78.8 mmol) and thionyl chloride (11 ml, 131.4 mmol) were added dropwise thereto and was stirred for 24 hours at 0° C. The reaction mixture was extracted with sodium bicarbonate and ethyl acetate, the organic layer was separated, and dried over anhydrous magnesium sulfate to obtain 5-chloromethyl benzo[1,3]dioxol (11.2 g, yield 100%).

Quelle