Reaktion #46128

Reaktionsgleichung

compound

4-cyclopropyl-3,4-dihydro-7-methoxycarbonyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

NaOH

→

title product

7-carboxy-4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

Lösungsmittel

methanol water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe methanol is then removed by distillation under reduced pressure
2. 2
   workup.ADDITIONby adding 6N HCl
3. 3
   SonstigeThe precipitate obtained
4. 4
   Filtrationis collected by filtration
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried

Vorschrift

A solution of the compound of Example 77 (3.5 mmol) in a mixture of methanol/water 1/1 (100 mL) containing NaOH (0.5 g) is heated at 40° C. for 3 hours. The methanol is then removed by distillation under reduced pressure and the resulting aqueous solution is adjusted to pH 2 by adding 6N HCl. The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.

Quelle