Reaktion #46123

Reaktionsgleichung

7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide

potassium carbonate

cyclopropylmethyl bromide

→

7-chloro-4-cyclopropylmethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is heated
2. 2
   Temperaturat reflux for 24 hours
3. 3
   SonstigeThe reaction mixture is evaporated under reduced pressure
4. 4
   FiltrationThe insoluble material is collected by filtration
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried
7. 7
   Sonstigeis recrystallised from methanol

Vorschrift

To a solution of 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (1 g) in acetonitrile (40 mL) there is added potassium carbonate (2.5 g) and cyclopropylmethyl bromide (0.7 mL) and the mixture is heated at reflux for 24 hours. The reaction mixture is evaporated under reduced pressure and the residue is taken up in water (40 mL). The insoluble material is collected by filtration, washed with water and dried and is recrystallised from methanol.

Quelle