Reaktion #46122

Reaktionsgleichung

2-amino-5-chlorobenzenesulphonamide

ethyl orthoformate

→

7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated
2. 2
   SonstigeThe precipitate obtained
3. 3
   Filtrationis collected by filtration
4. 4
   Waschenwashed with ether
5. 5
   Sonstigedried

Vorschrift

A mixture of 2-amino-5-chlorobenzenesulphonamide (obtained according to J. Chem. Soc. Perkin I, 1043-1047, 1979) and ethyl orthoformate (40 mL) is heated at boiling for 30 minutes in an open vessel. The volume of the mixture is reduced by half under reduced pressure. The precipitate obtained is collected by filtration, washed with ether and dried.

Quelle