Reaktion #46117

ord-d3c399511b97447abf51faf290d79fe9

Reaktionsgleichung

NS(=O)(=O)c1cc([N+](=O)[O-])ccc1NC1CC1
2-cyclopropylamino-5-nitrobenzenesulphonamide
CCOC([O-])[O-]
ethyl orthoformate
→
O=[N+]([O-])c1ccc2c(c1)S(=O)(=O)N=CN2C1CC1
4-cyclopropyl-7-nitro-4H-1,2,4-benzothiadiazine 1,1-dioxide

Edukte

NS(=O)(=O)c1cc([N+](=O)[O-])ccc1NC1CC1
2-cyclopropylamino-5-nitrobenzenesulphonamide
CCOC([O-])[O-]
ethyl orthoformate

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
130°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe suspension obtained
  2. 2
    Temperaturis cooled on an ice bath
  3. 3
    Filtrationthe insoluble material is collected by filtration
  4. 4
    Waschenwashed with ether
  5. 5
    Sonstigedried

Vorschrift

In a round-bottom flask, a mixture of 2-cyclopropylamino-5-nitrobenzenesulphonamide (5 g), originating from the Step above, and ethyl orthoformate (50 mL) is heated in the open state at 130° C. for 3 hours. The suspension obtained is cooled on an ice bath and the insoluble material is collected by filtration, washed with ether and dried.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07741320B2uspto-grants-2010_06