Reaktion #46079

Reaktionsgleichung

n-butyl lithium

3-chloropropylsulfonylamine tert-butylcarbamate

→

cyclopropylsulfonylamine tert-butyl carbamate

Ausbeute 100.0%

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe dry ice bath was removed
2. 2
   Temperaturto warm to room temperature over a period of 2 hours
3. 3
   SonstigeThe reaction mixture was quenched with glacial acetic acid (3.4 mL)
4. 4
   Einengenconcentrated in vacuo
5. 5
   Sonstigepartitioned between dichloromethane (100 mL) and water (100 mL)
6. 6
   WaschenThe organic phase was washed with brine (100 mL)
7. 7
   Trocknendried (MgSO4)
8. 8
   Filtrationfiltered
9. 9
   Einengenconcentrated in vacuo

Vorschrift

A solution of n-butyl lithium (74.7 mL, 119.5 mmol, 1.6M in hexane) was dissolved in dry THF (105 mL) and cooled to −78° C. under a Argon atmosphere. To this solution was added a solution of 3-chloropropylsulfonylamine tert-butylcarbamate (14 g, 54.3 mmol) in dry THF (105 mL) dropwise over 20-30 minutes. The dry ice bath was removed and the reaction mixture was allowed to warm to room temperature over a period of 2 hours. The reaction mixture was quenched with glacial acetic acid (3.4 mL), concentrated in vacuo, and partitioned between dichloromethane (100 mL) and water (100 mL). The organic phase was washed with brine (100 mL), dried (MgSO4), filtered, and concentrated in vacuo to afford the cyclopropylsulfonylamine tert-butyl carbamate as a waxy off-white solid (12.08 g, 100%): 1H NMR (CDCl3) δ 1.10 (m, 2H), 1.34 (m, 2H), 1.50 (s, 9H), 2.88 (m, 1H), 7.43 (s, 1H). 13C NMR (CDCl3) δ 6.21, 28.00, 31.13, 84.07, 149.82.

Quelle