Reaktion #460763

Reaktionsgleichung

2,2-dimethyl-1,2,3,4-tetrahydroquinoline

2-bromo-4'-fluoroacetophenone

→

N-(4-fluorobenzoylmethyl)-2,2-dimethyl-1,2,3,4-tetrahydroquinoline

Ausbeute 85.2%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated at 70°-80° C. for 5 hours under nitrogen
2. 2
   workup.ADDITIONThe reaction mixture was poured
3. 3
   Sonstigewas triturated with diethyl ether
4. 4
   Sonstigeto give pale yellow crystals
5. 5
   SonstigeThe crystals were collected
6. 6
   Waschenwashed with methanol

Vorschrift

A stirred mixture of 2,2-dimethyl-1,2,3,4-tetrahydroquinoline (4.69 g) and 2-bromo-4'-fluoroacetophenone (3.17 g) in dry N,N-dimethylformamide (6 ml) was heated at 70°-80° C. for 5 hours under nitrogen. The reaction mixture was poured was triturated with diethyl ether to give pale yellow crystals. The crystals were collected and washed with methanol to give N-(4-fluorobenzoylmethyl)-2,2-dimethyl-1,2,3,4-tetrahydroquinoline (3.7 g).

Quelle