Reaktion #460674

Reaktionsgleichung

5-(4-Chlorophenyl)-3-(3-hydroxypropyl)-1-(4-methoxyphenyl) pyrazole

2,2,6-trimethyl-1,3-dioxen-4-one

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59

Ausbeute 80.0%

3-(3-Acetoacetoxypropyl)-5-(4-chlorophenyl)-1-(4-methoxyphenyl) pyrazole

Ausbeute 80.0%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 16 hours
2. 2
   Einengenconcentrated in vacuo to a yellow oil
3. 3
   Sonstigechromatographed on silica gel

Vorschrift

5-(4-Chlorophenyl)-3-(3-hydroxypropyl)-1-(4-methoxyphenyl) pyrazole (1.71 g, 0.005 moles) and 2,2,6-trimethyl-1,3-dioxen-4-one (0.71 g, 0.005 moles) were dissolved in 100 ml of xylenes. The solution was stirred under reflux for 16 hours. At that time, the solution was cooled to room temperature, and concentrated in vacuo to a yellow oil. The oil was flash chromatographed on silica gel to afford 59 (1.7 g, 80%) as a pale yellow oil.

Quelle