Reaktion #460643

Reaktionsgleichung

n-butyllithium

ammonium chloride

1-ethoxyethyl-N,N-dimethyllactamide

hexyne

→

2-hydroxy-4-nonyn-3-one

Lösungsmittel

n-hexane

water

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas dropped
2. 2
   workup.STIRRINGThe resulting mixture was stirred at the same temperature as above for two hours
3. 3
   Sonstigeto terminate
4. 4
   Sonstigethe reaction

Vorschrift

A solution of 22 g of hexyne in 300 ml of THF was placed in a flask, and cooled to -50° C. Then, 170 ml of a 1.55M n-hexane solution of n-butyllithium was dropped thereto. The resulting mixture was stirred at -50° C. for 15 minutes, and then a solution of 50 g of (S) 1-ethoxyethyl-N,N-dimethyllactamide as obtained in Example 1 (2) in 150 ml of THF was dropped thereto. The resulting mixture was stirred at the same temperature as above for two hours, and then an aqueous solution of 28.3 g of ammonium chloride in 200 ml of water was dropped to terminate the reaction.

Quelle