Reaktion #460635

Reaktionsgleichung

benzyl chloride

4-Fluoro-2-methylthio-6-hydrazinopyrimidine

carbon disulfide

triethylamine

→

title compound

Ausbeute 79.3%

3-Benzylthio-7-fluoro-5-methylthio-1,2,4-triazolo[4,3-c]pyrimidine

Ausbeute 79.3%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturto reflux
3. 3
   workup.STIRRINGwith stirring for 2.5 hours
4. 4
   workup.STIRRINGwith stirring
5. 5
   Sonstigeto react for 3 hours
6. 6
   SonstigeThe volatiles were removed by evaporation under reduced pressure
7. 7
   workup.DISSOLUTIONthe residue was dissolved in methylene chloride
8. 8
   ExtraktionThe resulting solution was extracted with water
9. 9
   Trocknendried over magnesium sulfate
10. 10
    Einengenconcentrated under reduced pressure
11. 11
    SonstigeThe residue was triturated with hexane
12. 12
    Filtrationfiltered

Vorschrift

4-Fluoro-2-methylthio-6-hydrazinopyrimidine (15.0 g, 0.086 mol), 15.5 ml (19.7 g, 0.258 mol) of carbon disulfide, 48 ml (34.8 g, 0.344 mol) of triethylamine, and 400 ml of ethanol were combined with stirring and after 15 min heated to reflux with stirring for 2.5 hours. The resulting mixture was allowed to cool to ambient temperature and then 16.4 g (0.129 mol) of benzyl chloride was added with stirring and allowed to react for 3 hours. The volatiles were removed by evaporation under reduced pressure and the residue was dissolved in methylene chloride. The resulting solution was extracted with water, dried over magnesium sulfate and concentrated under reduced pressure. The residue was triturated with hexane and filtered to obtain 20.9 g of the title compound as a yellow-orange powder melting at 74°-77° C. There was also a small amount of 2-benzylthio-7-fluoro-5-methylthio-1,2,4-triazolo[1,5-c]pyrimidine present. The nmr and uv spectra were consistent with the assigned structure and the presence of the impurity.

Quelle