Reaktion #46060

Reaktionsgleichung

sodium bicarbonate

neopentyl glycol

1,3-dichloroacetone

benzene

→

2,2-bis-chloromethyl-5,5-dimethyl-1,3-dioxolane

Ausbeute 34.6%

Lösungsmittel

water

—

hexanes

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThis compound was synthesized
2. 2
   TrocknenThe organic layer was dried over anhydrous magnesium sulfate
3. 3
   Einengenconcentrated in vacuo

Vorschrift

This compound was synthesized by substantially following the procedure of the above-mentioned article by Isaka, Ejiri, and Nakamura. 69 grams of neopentyl glycol, 76 grams of 1,3-dichloroacetone, 50 ml of benzene, and 2.3 g of p-toluenesulfonic acid were refluxed through a Dean-Stark water separator for 8 hours whereon the reaction was diluted with hexanes and neutralized with aqueous sodium bicarbonate. The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuo yielding 41.2 g of 2,2-bis-chloromethyl-5,5-dimethyl-1,3-dioxolane, a pale yellow liquid.

Quelle