Reaktion #46056

Reaktionsgleichung

5-Chloro-1H-benzotriazole

Nitric acid

→

[ 22 ]

Ausbeute 83.0%

4-Nitro-5-chloro-1H-benzotriazole

Ausbeute 83.0%

Lösungsmittel

sulphuric acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat 60° C. for an additional 1 hour
2. 2
   TemperaturThe solution was cooled to room temperature
3. 3
   workup.ADDITIONpoured over ice
4. 4
   Sonstigeto precipitate a white solid
5. 5
   FiltrationThe solid was collected by filtration
6. 6
   Waschenwashed with copious amounts of water until neutral

Vorschrift

5-Chloro-1H-benzotriazole (3.08 g, 20 mmol) was dissolved in conc. sulphuric acid (40 ml) and cooled to 0° C. on an ice bath. Nitric acid (40 ml, excess) was added drop wise to the cooled solution over a period of 20 minutes. Stirring was continued for 1 hour at 0° C. and then at 60° C. for an additional 1 hour, by which time TLC (A) indicated the conversion of starting material. The solution was cooled to room temperature and poured over ice to precipitate a white solid. The solid was collected by filtration and washed with copious amounts of water until neutral to afford [22] in 83% yield. Rf (A) 0.49 δH(400 MHz; DMSO-d6) 7.75 (1H, d, J8.8, BT) 8.38 (1H, br s, BT); m/z (EI−HR) 197.99383 [(M) calc. for C6H3N4O235Cl 197.99445] and 199.99345 [(M) calc. for C6H3N4O237Cl 199.99150].

Quelle