Reaktion #46014

Reaktionsgleichung

EtOAc

4-chloro-3-ethylphenol

1-fluoro-4-nitrobenzene

potassium carbonate

→

4-(4-chloro-3-ethylphenoxy)-1-nitrobenzene

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to rt
2. 2
   Waschenwashed with H2O (2×50 mL) and brine (50 mL)
3. 3
   Trocknendried over sodium sulfate
4. 4
   SonstigeThe solvent was removed in vacuuo

Vorschrift

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 4-chloro-3-ethylphenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into EtOAc (100 mL), washed with H2O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(4-chloro-3-ethylphenoxy)-1-nitrobenzene. The crude product was used for further transformation.

Quelle