Reaktion #4601

Reaktionsgleichung

BH3.THF

1-Methyl cyclohexanecarboxylic acid

BH3.THF

→

1-methyl-1-cyclohexylmethanol

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA three liter, three necked round bottom flask was equipped with a thermometer, magnetic stirrer, argon inlet and outlet adapters and a one liter addition funnel
2. 2
   Temperaturmaintaining the temperature between 5°-15° C
3. 3
   workup.ADDITIONAfter the addition
4. 4
   Sonstigethe ice bath was removed
5. 5
   workup.ADDITIONA much slower addition rate
6. 6
   Temperaturconstant cooling should
7. 7
   workup.ADDITION150 ml of methanol was added cautiously
8. 8
   Temperaturusing low heat
9. 9
   workup.ADDITIONthe residue was treated with 100 ml of 5% acetic acid
10. 10
    workup.STIRRINGAfter stirring for thirty min
11. 11
    Sonstigethe reaction was transferred to a one liter separatory funnel
12. 12
    workup.ADDITIONdiluted with water (slurry dissolved)
13. 13
    Extraktionextracted three times with ether
14. 14
    WaschenThe combined ether extracts were washed twice with saturated sodium bicarbonate, twice with brine
15. 15
    Trocknendried over anhydrous magnesium sulfate
16. 16
    Filtrationfiltered through celite and
17. 17
    Einengenconcentrated in vacuo (low heat)
18. 18
    Sonstigeto give 79.09 g of a clear water-white oil
19. 19
    workup.DISTILLATIONThe oil was distilled on a Kugelrohr apparatus at 75°-130° C. (25 mm of Hg)
20. 20
    workup.DISTILLATIONMost distilled at 90° C.

Vorschrift

A three liter, three necked round bottom flask was equipped with a thermometer, magnetic stirrer, argon inlet and outlet adapters and a one liter addition funnel containing 922 ml of 1.0 molar BH3.THF. 1-Methyl cyclohexanecarboxylic acid (119.2 g; 0.84 m) was added to the reaction vessel and dissolved in 100 ml of THF. The reaction mixture was cooled with an ice bath to 5° C. and the BH3.THF was added dropwise over 25 min maintaining the temperature between 5°-15° C. After the addition was complete, the ice bath was removed. After about five min, the reaction exothermed and foamed violently. A much slower addition rate and constant cooling should help to avoid this exotherm. The reaction was allowed to stir for two hr at RT under nitrogen, then 150 ml of methanol was added cautiously. When the foaming ceased, the reaction was concertrated in vacuo using low heat and the residue was treated with 100 ml of 5% acetic acid. After stirring for thirty min, the reaction was transferred to a one liter separatory funnel, diluted with water (slurry dissolved) and extracted three times with ether. The combined ether extracts were washed twice with saturated sodium bicarbonate, twice with brine, dried over anhydrous magnesium sulfate, filtered through celite and concentrated in vacuo (low heat) to give 79.09 g of a clear water-white oil. The oil was distilled on a Kugelrohr apparatus at 75°-130° C. (25 mm of Hg). Most distilled at 90° C. to give 72.11 g of 1-methyl-1-cyclohexylmethanol.

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