Reaktion #45965

Reaktionsgleichung

N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine

→

4-(N,N-diethylaminopropoxy)aniline

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was then filtered
2. 2
   Sonstigeto remove the catalyst
3. 3
   SonstigeThe solvent was removed in vacuuo

Vorschrift

The N,N-diethyl-N-[3-(4-nitrophenoxy)propyl]amine (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-(N,N-diethylaminopropoxy)aniline, which was used directly for further transformation without further purification.

Quelle