Reaktion #459372

Reaktionsgleichung

β-(4-aminocarbonylphenoxy)-ethylamine

1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane

1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane

→

1-[β-(4-aminocarbonylphenoxy)-ethylamino]-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeaccording to the invention of preparing further compounds of formula I of the invention
2. 2
   workup.ADDITION11 (1973)) is added to a solution
3. 3
   workup.ADDITIONcontaining 0.4 g
4. 4
   Sonstigeat 20° C
5. 5
   SonstigeThe mixture is then evaporated to dryness
6. 6
   Sonstigeyielding a crude residue which
7. 7
   Sonstigeis then further purified by thin-layer chromatography on silica gel

Vorschrift

This example illustrates further methods according to the invention of preparing further compounds of formula I of the invention. In this example 1 g. of β-(4-aminocarbonylphenoxy)-ethylamine (Cox et al, J. Med. Chem., v. 16, No. 11 (1973)) is added to a solution containing 0.4 g. of 1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane in 20 ml. of anhydrous absolute ethanol at 20° C. The resulting mixture is monitored by thin-layer chromatographic analysis and allowed to stand until conversion of the 1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane is essentially complete. The mixture is then evaporated to dryness yielding a crude residue which is then further purified by thin-layer chromatography on silica gel yielding 1-[β-(4-aminocarbonylphenoxy)-ethylamino]-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol.

Quelle