Reaktion #459371

Reaktionsgleichung

1,2-epoxy-3-(5-aminocarbonylthiazol-2-oxy)-propane

morpholine

1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane

→

N-morpholino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeaccording to the invention of preparing the compounds of formula I to the invention
2. 2
   workup.ADDITIONcontaining 0.3 g
3. 3
   Sonstigeat 20° C
4. 4
   SonstigeThe mixture is then evaporated to dryness

Vorschrift

This example illustrates further methods according to the invention of preparing the compounds of formula I to the invention. In this example 1 g. of morpholine is added to a solution containing 0.3 g. of 1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane in 20 ml. of anhydrous absolute ethanol at 20° C. The resulting mixture is monitored by thin-layer chromatographic analysis and allowed to stand until conversion of the 1,2-epoxy-3-(5-aminocarbonylthiazol-2-oxy)-propane is essentially complete. The mixture is then evaporated to dryness yielding a crude residue of 1 -(N-morpholino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol which is then further purified by thin-layer chromatography on silica gel.

Quelle