Reaktion #459123

Reaktionsgleichung

1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane

sodium carbonate

p-chlorobenzoyl chloride

→

3-p-Chlorobenzoyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe benzene is evaporated
2. 2
   workup.DISSOLUTIONthe dark purple residue is dissolved in 200 ml
3. 3
   Waschenof chloroform and washed successively with 5% sodium carbonate, 0.5N Hydrochloric acid
4. 4
   Trocknenwith water and dried over sodium sulfate giving a dark purple oil
5. 5
   ExtraktionThe oil is extracted with ether giving the product as grey crystals, mp 98°-100° C.

Vorschrift

Following the procedure of Example 8, 19.35 g. of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane, 10.59 g. of sodium carbonate and 17.5 g. of p-chlorobenzoyl chloride are reacted. The benzene is evaporated and the dark purple residue is dissolved in 200 ml. of chloroform and washed successively with 5% sodium carbonate, 0.5N Hydrochloric acid and then with water and dried over sodium sulfate giving a dark purple oil. The oil is extracted with ether giving the product as grey crystals, mp 98°-100° C.

Quelle