Reaktion #459120

Reaktionsgleichung

1-phenyl-3-azabicyclo[3.1.0]-hexane

sodium carbonate

m-fluorobenzoyl chloride

benzene

→

3-m-Fluorobenzoyl-1-phenyl-3-azabicyclo[3.1.0]hexane

Lösungsmittel

ether

—

petroleum ether

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture is stirred overnight
2. 2
   ExtraktionThe oil present in the aqueous layer is extracted with chloroform
3. 3
   Waschenwashed successively with water, dilute hydrochloric acid and water
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated
7. 7
   Sonstigegiving an oil
8. 8
   Sonstigethe product is recovered as a white solid, mp 68°-69.5° C.

Vorschrift

A 6.4 g. portion of 1-phenyl-3-azabicyclo[3.1.0]-hexane is added to 60 ml. of benzene. A 4.2 g. portion of sodium carbonate in 40 ml. of water is added with stirring. A 6.3 g. portion of m-fluorobenzoyl chloride is added and the mixture is stirred overnight. The oil present in the aqueous layer is extracted with chloroform, washed successively with water, dilute hydrochloric acid and water, dried over magnesium sulfate, filtered and evaporated giving an oil. This oil is dissolved in ether. A small amount of petroleum ether is added and the product is recovered as a white solid, mp 68°-69.5° C.

Quelle