Reaktion #459119

Reaktionsgleichung

1-phenyl-3-azabicyclo[3.1.0]-hexane

sodium carbonate

p-fluorobenzoyl chloride

→

3-p-Fluorobenzoyl-1-phenyl-3-azabicyclo[3.1.0]hexane

Lösungsmittel

benzene

benzene

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture is stirred overnight
2. 2
   FiltrationThe solid in the aqueous layer is recovered by filtration
3. 3
   Waschenwashed with water

Vorschrift

A 6.4 g. portion of 1-phenyl-3-azabicyclo[3.1.0]-hexane is added to 60 ml. of benzene. A 4.2 g. portion of sodium carbonate in 40 ml. of water is added with stirring. A 6.3 g. portion of p-fluorobenzoyl chloride in 40 ml. of benzene is added and the mixture is stirred overnight. The solid in the aqueous layer is recovered by filtration, washed with water and slurried in ether giving the product as white crystals, mp 101°-103° C.

Quelle