Reaktion #459115

Reaktionsgleichung

1-phenyl-3-azabicyclo[3.1.0]hexane

pyridine

acetic anhydride

→

3-Acetyl-1-phenyl-3-azabicyclo[3.1.0]hexane

Lösungsmittel

ether

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated
2. 2
   Sonstigeto give an oil
3. 3
   Waschenwashed with dilute hydrochloric acid
4. 4
   Trocknensodium bicarbonate and dried over magnesium sulfate
5. 5
   Sonstigeevaporated to a pale amber liquid
6. 6
   SonstigeThis liquid is crystallized from hexane
7. 7
   Sonstigeto give the product, mp 63°-65° C.

Vorschrift

To 15.9 g. of 1-phenyl-3-azabicyclo[3.1.0]hexane in 20 ml. of pyridine is added 20 ml. of acetic anhydride. The mixture is allowed to stand overnight at room temperature and then evaporated to give an oil. This oil is dissolved in a mixture of ether and methylene chloride, washed with dilute hydrochloric acid and then sodium bicarbonate and dried over magnesium sulfate and evaporated to a pale amber liquid. This liquid is crystallized from hexane to give the product, mp 63°-65° C.

Quelle