Reaktion #459114

Reaktionsgleichung

cyclopropanecarboxylic acid chloride

1-phenyl-3-azabicyclo-[3.1.0]hexane

benzene

benzene

triethylamine

→

product

3-Cyclopropylcarbonyl-1-phenyl-3-azabicyclo[3.1.0]hexane

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe benzene layer is extracted with dilute sodium bicarbonate
2. 2
   Trocknenwater, dried over magnesium sulfate
3. 3
   Sonstigeevaporated

Vorschrift

To a solution of 15.9 g. of 1-phenyl-3-azabicyclo-[3.1.0]hexane in 100 ml. of benzene and 20 ml. of triethylamine is added 11.0 g. of cyclopropanecarboxylic acid chloride in 20 ml. of benzene over 5 minutes. The mixture is stirred for 30 minutes and 50 ml. of water is added. The benzene layer is extracted with dilute sodium bicarbonate followed by dilute hydrochloric acid and then water, dried over magnesium sulfate and evaporated to give the product as a brown oil.

Quelle