Reaktion #459020

ord-827578e6bee44830ace8c9645d5d482d

Reaktionsgleichung

CCC(=O)O.CCC(=O)O.C[C@H]1C[C@H]2[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]2[C@@]2(CO)C=CC(=O)C=C12
17β,19-dihydroxy-6α-methyl-1,4-androstadien-3-one dipropionate
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43CO)[C@@H]1CC[C@@H]2O
17β,19-dihydroxy-1,4-androstadien-3-one
→
CCC(=O)O.CCC(=O)O.C[C@H]1C[C@H]2[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]2[C@]2(CO)C1=CC(=O)C[C@@H]2C
17β,19-dihydroxy-1α,6α-dimethyl-4-androsten-3-one dipropionate

Edukte

CCC(=O)O.CCC(=O)O.C[C@H]1C[C@H]2[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]2[C@@]2(CO)C=CC(=O)C=C12
17β,19-dihydroxy-6α-methyl-1,4-androstadien-3-one dipropionate
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43CO)[C@@H]1CC[C@@H]2O
17β,19-dihydroxy-1,4-androstadien-3-one

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Substituting 17β,19-dihydroxy-17α-methyl-1,4-androstadien-3-one dipropionate and 17β,19-dihydroxy-6α-methyl-1,4-androstadien-3-one dipropionate for 17β,19-dihydroxy-1,4-androstadien-3-one in the above procedure results in the formation of 17β,19-dihydroxy-1α,17α-dimethyl-4-androsten-3-one dipropionate and 17β,19-dihydroxy-1α,6α-dimethyl-4-androsten-3-one dipropionate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04087524uspto-grants-1978_05