Reaktion #4584

Reaktionsgleichung

2-(2-propanon-1-yloxy)phenylsulfonamide

ethylene glycol

p-toluenesulfonic acid

toluene

→

2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated for 7 hours
2. 2
   Temperaturto reflux
3. 3
   Sonstigewhile simultaneously separating
4. 4
   Sonstigethe water of reaction
5. 5
   Waschenthe organic phase is washed with saturated sodium bicarbonate solution and water
6. 6
   Sonstigedried
7. 7
   Einengenconcentrated

Vorschrift

A mixture of 4.58 g of 2-(2-propanon-1-yloxy)phenylsulfonamide, 2 ml of ethylene glycol, 0.02 g of p-toluenesulfonic acid and 30 ml of toluene is heated for 7 hours to reflux while simultaneously separating the water of reaction. The cooled solution is taken up in 80 ml of ethyl acetate and the organic phase is washed with saturated sodium bicarbonate solution and water, dried and concentrated, affording 5 g of 2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide in the form of a yellow viscous oil which can be further used without purification.

Quelle