Reaktion #458332

Reaktionsgleichung

ammonium chloride

N-ethoxycarbonyl-2,3-dihydro-4(1H)-pyridinone

magnesium

2-benzyloxy-1-bromo-4-(1,1-dimethylheptyl)benzene

→

title compound

Ausbeute 71.0%

N-Ethoxycarbonyl-2-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-piperidinone

Ausbeute 71.0%

Lösungsmittel

ether

ether

ether

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat such a rate that gentle reflux
2. 2
   Temperaturthe mixture cooled to -12° C.
3. 3
   ExtraktionThe organic extract
4. 4
   Waschenis washed with three 600 ml portions of saturated ammonium chloride
5. 5
   Trocknendried over magnesium sulfate
6. 6
   Sonstigeevaporated to an oil
7. 7
   SonstigeThis crude product is purified via column chromatography on 2 kg of silica gel eluting in 500 ml fractions with 50% ether-hexane

Vorschrift

To 3.45 (0.142 mole) of magnesium is added a solution of 27.6 g (0.071 mole) of 2-benzyloxy-1-bromo-4-(1,1-dimethylheptyl)benzene in 71 ml of tetrahydrofuran, at such a rate that gentle reflux occurs. The Grignard solution is allowed to cool to 25° C. over 30 minutes, diluted with 71 ml of ether, the mixture cooled to -12° C. and 2.13 g (0.0112 mole) cuprous iodide is added followed by addition of 8.00 g (0.0473 mole) of N-ethoxycarbonyl-2,3-dihydro-4(1H)-pyridinone in 47 ml of ether over 20 minutes. The reaction is stirred 30 minutes longer at -12° C. and then added to 2 liters ether and 600 ml saturated ammonium chloride. The organic extract is washed with three 600 ml portions of saturated ammonium chloride, dried over magnesium sulfate and evaporated to an oil. This crude product is purified via column chromatography on 2 kg of silica gel eluting in 500 ml fractions with 50% ether-hexane to yield (fractions 17-24) 16.0 g (71%) of the title compound as an oil.

Quelle