Reaktion #45828

Reaktionsgleichung

N-Bromosuccinimide

N,N-dimethylformamide

2-amino-4-fluoro-6-methylbenzonitrile

→

compound

Ausbeute 95.0%

6-Amino-3-bromo-4-fluoro-2-methylbenzonitrile

Ausbeute 95.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe reaction liquid
2. 2
   Filtrationthe precipitated solid was collected by filtration
3. 3
   WaschenThe solid was washed with water
4. 4
   Sonstigedried

Vorschrift

N-Bromosuccinimide (16.6 g, 93.3 mmol) was gradually added to an N,N-dimethylformamide (250 ml) solution of 2-amino-4-fluoro-6-methylbenzonitrile (I-264) (14.0 g, 93.3 mmol). After stirring for 6 hours, the reaction liquid was poured into water with ice (750 ml), the precipitated solid was collected by filtration. The solid was washed with water, then dried to obtain the entitled compound (20.2 g, 95%) as a gray solid.

Quelle