Reaktion #4582

Reaktionsgleichung

phosgene

2-(1-methoxycarbonylethoxy)-benzenesulfonamide

n-butylisocyanate

phosgene

→

2-(1-methoxycarbonylethoxy)benzenesulfonyl isocyanate

Ausbeute 125.5%

Lösungsmittel

xylene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 30 minutes
2. 2
   Temperaturthe solution is then cooled
3. 3
   Einengenconcentrated in vacuo

Vorschrift

A mixture of 12.9 g of 2-(1-methoxycarbonylethoxy)-benzenesulfonamide, 4.9 g of n-butylisocyanate and 0.1 g of diazabicyclooctane and 130 ml of xylene is refluxed for 30 minutes. Then 10 g of phosgene are passed into the solution at the same temperature over 90 minutes. Excess phosgene is expelled with nitrogen and the solution is then cooled and concentrated in vacuo, affording 17.7 g of 2-(1-methoxycarbonylethoxy)benzenesulfonyl isocyanate in the form of a brownish oil which can be further used without purification.

Quelle