Reaktion #4579

Reaktionsgleichung

sodium hydroxide

α-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-α-isopropyl-α-methyl-acetamide

water

→

title compound

3-isopropyl-3-methyl-7-n-propyl-3H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5-dione

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter the reaction solution has cooled
2. 2
   Filtrationit is filtered through silica gel
3. 3
   Waschenthe filtrate is washed with ethyl acetate
4. 4
   Einengenconcentrated by evaporation
5. 5
   SonstigeThe residue is recrystallised from ethyl acetate/petroleum ether

Vorschrift

With the simultaneous addition of 0.5 g of powdered sodium hydroxide, a solution of α-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-α-isopropyl-α-methyl-acetamide (m.p.: 82° C.) in 100 ml of toluene is heated under reflux for 2 hours in a water separator. After the reaction solution has cooled, it is filtered through silica gel and the filtrate is washed with ethyl acetate and then concentrated by evaporation. The residue is recrystallised from ethyl acetate/petroleum ether, affording 13.1 g of the title compound which melts at 116° C.

Quelle