Reaktion #4577

Reaktionsgleichung

methyl 5-chlorooxindole-3-carboxylate

phenylisocyanate

→

Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

Lösungsmittel

toluene

—

petroleum ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturto reflux overnight
3. 3
   TemperaturThe reaction mixture was cooled
4. 4
   Sonstigeto give
5. 5
   Filtrationafter filtration
6. 6
   Sonstigedrying

Vorschrift

To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.

Quelle