Reaktion #4576

Reaktionsgleichung

2-oxindole

isopropyl isocyanate

→

title compound

1-N-i-Propylcarbamoyloxindole

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo a stirred suspension of 5.0 g
2. 2
   Temperaturunder reflux for 6 hours
3. 3
   Temperaturto cool
4. 4
   SonstigeThe solvent was removed by evaporation in vacuo
5. 5
   workup.DISSOLUTIONthe residue was dissolved in hot cyclohexane
6. 6
   Temperaturto cool
7. 7
   Filtrationthe solid was collected by filtration
8. 8
   Sonstigegiving 7.0 g

Vorschrift

To a stirred suspension of 5.0 g. (37.6 mmole) of 2-oxindole in 50 ml. of toluene was added 8.0 g. (94.0 mmole) of isopropyl isocyanate, and the mixture was heated under reflux for 6 hours. The reaction mixture was allowed to cool and then it was stirred at room temperature overnight. The solvent was removed by evaporation in vacuo, and the residue was dissolved in hot cyclohexane. The solution was allowed to cool and the solid was collected by filtration, giving 7.0 g. of the title compound, m.p. 84°-85.5° C., as pink crystals.

Quelle