Reaktion #457078

ord-eae14b1ec0d847ed8a98c90edada3047

Reaktionsgleichung

CC(C)c1cc(C(=O)/C=C/C(=O)N2CCN(C)CC2)ccc1OCC(=O)Nc1nc2ccccc2s1
2-{2-isopropyl-4-[trans-3-(4-methyl-1-piperazinyl)carbonylacryloyl]phenoxymethylcarbonylamino}benzothiazole
O
water
→
CC(C)c1cc(C(=O)/C=C\C(=O)N2CCN(C)CC2)ccc1OCC(=O)Nc1nc2ccccc2s1
2-{2-isopropyl-4-[cis-3-(4-methyl-1-piperazinyl)carbonylacryloyl]phenoxymethylcarbonylamino}benzothiazole
Ausbeute 45.0%

Edukte

CC(C)c1cc(C(=O)/C=C/C(=O)N2CCN(C)CC2)ccc1OCC(=O)Nc1nc2ccccc2s1
2-{2-isopropyl-4-[trans-3-(4-methyl-1-piperazinyl)carbonylacryloyl]phenoxymethylcarbonylamino}benzothiazole
O
water

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
dimethylformamide

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Filtrationthe precipitated crystals are collected by filtration
  2. 2
    Sonstigerecrystallized from ethanol

Vorschrift

A solution of 2-{2-isopropyl-4-[trans-3-(4-methyl-1-piperazinyl)carbonylacryloyl]phenoxymethylcarbonylamino}benzothiazole (100 mg) in dimethylformamide (10 ml) is allowed to stand for 6.5 hours by a window in order to be exposed to direct sunlight. To the mixture is added water, the precipitated crystals are collected by filtration, and recrystallized from ethanol to give 2-{2-isopropyl-4-[cis-3-(4-methyl-1-piperazinyl)carbonylacryloyl]phenoxymethylcarbonylamino}benzothiazole (45 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06140330uspto-grants-2000_10