Reaktion #457058

Reaktionsgleichung

water

2-(2-isopropylphenoxymethylcarbonylamino)benzothiazole

chloroacetyl chloride

aluminum chloride

→

2-[2-isopropyl-4-(2-chloroacetyl)phenoxymethylcarbonylamino]benzothiazole

Lösungsmittel

n-hexane

1,2-dichloroethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture is stirred at room temperature for one hour
2. 2
   FiltrationThe precipitates are collected by filtration
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried

Vorschrift

To a solution of chloroacetyl chloride (10.0 ml) in anhydrous 1,2-dichloroethane (250 ml) is added aluminum chloride (12 g) at room temperature, and the mixture is stirred for 20 minutes. To the mixture is added at once 2-(2-isopropylphenoxymethylcarbonylamino)benzothiazole (20 g), and the mixture is stirred at room temperature for one hour. The reaction mixture is poured into water, and thereto is added n-hexane. The precipitates are collected by filtration, washed with water, and dried to give 2-[2-isopropyl-4-(2-chloroacetyl)phenoxymethylcarbonylamino]benzothiazole (25.9 g).

Quelle