Reaktion #457050

Reaktionsgleichung

4-(3-chloro-anilino)-6-ethoxycarbonyl-7H-pyrrolo[2,3-d]pyrimidine

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title compound

4-(3-Chloro-anilino)-6-[N-(3-methyl-but-1-yl)-carbamoyl]-7H-pyrrolo[2,3-d]pyrimidine

Lösungsmittel

(3-methyl-but-1-yl)-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture is concentrated by evaporation
2. 2
   workup.DISSOLUTIONthe residue is dissolved in THF
3. 3
   Einengenconcentrated by evaporation again
4. 4
   Filtrationfiltered

Vorschrift

95 mg (0.30 mmol) of 4-(3-chloro-anilino)-6-ethoxycarbonyl-7H-pyrrolo[2,3-d]pyrimidine in 1 ml of (3-methyl-but-1-yl)-amine are heated at 80° C. for 12 hours. The reaction mixture is concentrated by evaporation, the residue is dissolved in THF, concentrated by evaporation again, stirred with diethyl ether and filtered, yielding the title compound; m.p. 304-306° C.; FAB-MS: (M+H)+ =358.

Quelle