Reaktion #456980

Reaktionsgleichung

3-cyclobutylbenzyl alcohol

PBr3

→

3-cyclobutyl benzyl bromide

Ausbeute 89.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford 1.69 g of crude product (92% pure by 1H-NMR)
2. 2
   SonstigeThis material was purified by flash chromatography on 65 g of silica gel (hexane)

Vorschrift

According to example 17, 1.29 g of 3-cyclobutylbenzyl alcohol was treated with 0.26 mL of PBr3 in 15 mL of anhydrous CH2Cl2 to afford 1.69 g of crude product (92% pure by 1H-NMR). This material was purified by flash chromatography on 65 g of silica gel (hexane) to afford 1.59 g (89%) of 3-cyclobutyl benzyl bromide as a clear liquid.

Quelle