Reaktion #456896

ord-9289d9a114744dd7accf6a10d1f409e5

Reaktionsgleichung

O=[N+]([O-])c1ccc(-c2cc3c(Cl)ncnc3[nH]2)cc1
4-chloro-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine
c1ccc2c(c1)CCCN2
1,2,3,4-tetrahydroquinoline
→
O=[N+]([O-])c1ccc(-c2cc3c(N4CCCc5ccccc54)ncnc3[nH]2)cc1
4-(1,2,3,4-Tetrahydroquinolin-1-yl)-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]-pyrimidine

Edukte

O=[N+]([O-])c1ccc(-c2cc3c(Cl)ncnc3[nH]2)cc1
4-chloro-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine
c1ccc2c(c1)CCCN2
1,2,3,4-tetrahydroquinoline

Reagenzien

Keine

Lösungsmittel

CC(C)=O.Cc1ccccc1
toluene acetone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThis product is prepared in a manner analogous to

Vorschrift

This product is prepared in a manner analogous to that described in Example 6 from 4-chloro-6-(4-nitro-phenyl)-7H-pyrrolo[2,3-d]pyrimidine and 1,2,3,4-tetrahydroquinoline (2.1 equivalents). FAB-MS: (M+H)+ =372 (corresponds to C21H17N5O2); Rf value (toluene-acetone--4:6)=0.36.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06140317uspto-grants-2000_10