Reaktion #45673

Reaktionsgleichung

N-bromosuccinimide

4-cyano-6-[1-(ethoxy)ethenyl]-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide

→

6-Bromoacetyl-4-cyano-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide

Lösungsmittel

tetrahydrofuran water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated away under reduced pressure
2. 2
   workup.DISSOLUTIONthe resulting residue was dissolved in ethyl acetate
3. 3
   Waschenthe solution was washed with water

Vorschrift

Next, at room temperature, N-bromosuccinimide (2.10 g, 11.8 mmol) was added to a tetrahydrofuran/water (178 ml/11 ml) mixed solution of the obtained 4-cyano-6-[1-(ethoxy)ethenyl]-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide (3.56 g, 11.2 mmol), and stirred for 20 minutes. The solvent was evaporated away under reduced pressure, and the resulting residue was dissolved in ethyl acetate, and the solution was washed with water.

Quelle