Reaktion #45670

Reaktionsgleichung

2-amino-5-bromo-4-fluoro-3-hydroxy-6-methylbenzonitrile

ethyl triethoxyacetate

→

compound

Ausbeute 80.0%

Ethyl 6-bromo-4-cyano-7-fluoro-5-methyl-1,3-benzoxazole-2-carboxylate

Ausbeute 80.0%

Lösungsmittel

n-hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Filtrationthe precipitated solid was collected by filtration
3. 3
   Waschenwashed in diethyl ether

Vorschrift

Under nitrogen atmosphere, a mixture of 2-amino-5-bromo-4-fluoro-3-hydroxy-6-methylbenzonitrile (I-75) (6.67 g, 27.2 mmol) and ethyl triethoxyacetate (24.0 g, 54.4 mmol) was stirred at 130° C. for 15 hours. After cooling, n-hexane was added to the reaction liquid, and the precipitated solid was collected by filtration. The obtained solid was suspended and washed in diethyl ether to obtain the entitled compound (7.10 g, 80%) as a pale dark brown solid.

Quelle