Reaktion #45640

Reaktionsgleichung

picolinic acid

(3S)-3-(dimethylamino)pyrrolidine

oxalyl chloride

4-amino-6-fluoro-5-hydroxy-2-methylbiphenyl-3-carbonitrile

diisopropylethylamine

→

7-[(3S)-3-(Dimethylamino)pyrrolidin-1-yl]-5-methyl-6-phenyl-2-(pyridin-2-yl)-1,3-benzoxazole-4-carbonitrile

Lösungsmittel

dichloromethane

dimethylformamide

triethylamine

chloroform

dimethyl sulfoxide

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGstirring at room temperature for 20 minutes
2. 2
   TemperaturAfter again cooling with ice
3. 3
   workup.ADDITIONwere added
4. 4
   workup.STIRRINGby stirring at room temperature for 2 hours
5. 5
   SonstigeThe reaction liquid
6. 6
   Waschenthe organic layer was washed with water
7. 7
   Trocknendried over anhydrous sodium sulfate
8. 8
   Sonstigethe solvent was evaporated away under reduced pressure
9. 9
   TemperaturThe resulting residue was heated
10. 10
    Temperaturunder reflux for 30 minutes in toluene (20 ml) in the presence of a catalytic amount of p-tosylic acid with a Dean-Stark device
11. 11
    TemperaturAfter cooling
12. 12
    Sonstigethe solvent was evaporated away
13. 13
    workup.DISSOLUTIONthe resulting residue was dissolved in chloroform
14. 14
    Waschenwashed with water
15. 15
    Trocknendried over anhydrous sodium sulfate
16. 16
    Sonstigethe solvent was evaporated away under reduced pressure
17. 17
    TemperaturThe resulting residue was heated
18. 18
    Temperaturunder reflux in xylene (20 ml) in the presence of a catalytic amount of p-tosylic acid with a Dean-Stark device
19. 19
    TemperaturAfter cooling
20. 20
    Sonstigethe solvent was evaporated away
21. 21
    workup.DISSOLUTIONthe resulting residue was dissolved in chloroform
22. 22
    Waschenwashed with water
23. 23
    Trocknendried over anhydrous sodium sulfate
24. 24
    Sonstigethe solvent was evaporated away under reduced pressure
25. 25
    WaschenThe resulting residue was washed with a mixed solvent of ethyl acetate and isopropyl ether
26. 26
    Filtrationthe precipitated solid was collected by filtration
27. 27
    Temperaturheated
28. 28
    Temperaturunder reflux for 15 hours in the presence of a catalytic amount of pyridinium p-toluenesulfonate
29. 29
    workup.ADDITIONa catalytic amount of p-toluenesulfonic acid was added
30. 30
    Temperaturby heating
31. 31
    Temperaturunder reflux for 12 hours
32. 32
    TemperaturAfter cooling
33. 33
    Sonstigethe solvent was evaporated away
34. 34
    workup.DISSOLUTIONthe resulting residue was dissolved in chloroform
35. 35
    Waschenwashed with water
36. 36
    Trocknendried over anhydrous sodium sulfate
37. 37
    Sonstigethe solvent was evaporated away under reduced pressure
38. 38
    Wascheneluted with a mixed solvent of chloroform/methanol (100:10
39. 39
    Sonstigev/v→98:2, v/v) to obtain a main product

Vorschrift

With cooling with ice, oxalyl chloride (262 μl, 3 mmol) and a catalytic amount of dimethylformamide were added to a dichloromethane (7 ml) suspension of picolinic acid (271 mg, 2.2 mmol), followed by stirring at the same temperature for 10 minutes and stirring at room temperature for 20 minutes. After again cooling with ice, a dichloromethane suspension of 4-amino-6-fluoro-5-hydroxy-2-methylbiphenyl-3-carbonitrile (I-41) (458 mg, 2.0 mmol) and diisopropylethylamine (697 μl, 4 mmol) were added, followed by stirring at room temperature for 2 hours. The reaction liquid was diluted with chloroform, then the organic layer was washed with water, dried over anhydrous sodium sulfate, and the solvent was evaporated away under reduced pressure. The resulting residue was heated under reflux for 30 minutes in toluene (20 ml) in the presence of a catalytic amount of p-tosylic acid with a Dean-Stark device. After cooling, the solvent was evaporated away, the resulting residue was dissolved in chloroform, washed with water, dried over anhydrous sodium sulfate, then the solvent was evaporated away under reduced pressure. The resulting residue was heated under reflux in xylene (20 ml) in the presence of a catalytic amount of p-tosylic acid with a Dean-Stark device. After cooling, the solvent was evaporated away, the resulting residue was dissolved in chloroform, washed with water, dried over anhydrous sodium sulfate, then the solvent was evaporated away under reduced pressure. The resulting residue was washed with a mixed solvent of ethyl acetate and isopropyl ether, the precipitated solid was collected by filtration. This was suspended in toluene (40 ml), and heated under reflux for 15 hours in the presence of a catalytic amount of pyridinium p-toluenesulfonate. Further, the solvent was changed to xylene, a catalytic amount of p-toluenesulfonic acid was added, followed by heating under reflux for 12 hours. After cooling, the solvent was evaporated away, and the resulting residue was dissolved in chloroform, washed with water, then dried over anhydrous sodium sulfate, and the solvent was evaporated away under reduced pressure. The resulting residue was subjected to silica gel column chromatography, and eluted with a mixed solvent of chloroform/methanol (100:10, v/v→98:2, v/v) to obtain a main product. This was dissolved in dimethyl sulfoxide (8 ml), and (3S)-3-(dimethylamino)pyrrolidine (129 μl, 1.02 mmol) and triethylamine (150 μl) were added.

Quelle