Reaktion #456281

ord-044b4722c6804e178f43391de65273df

Reaktionsgleichung

O=C(CC(=O)C(F)(F)F)c1nc2ccc(F)cc2o1
1-(6-fluorobenzoxazol-2-yl)-4,4,4-trifluorobutane-1,3-dione
CS(=O)(=O)c1ccc(NN)cc1.Cl
4-methylsulfonylphenylhydrazine hydrochloride
→
CS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2nc3ccc(F)cc3o2)cc1
6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-trifluoromethyl-1H-pyrazol-5-yl]benzoxazole

Edukte

O=C(CC(=O)C(F)(F)F)c1nc2ccc(F)cc2o1
1-(6-fluorobenzoxazol-2-yl)-4,4,4-trifluorobutane-1,3-dione
CS(=O)(=O)c1ccc(NN)cc1.Cl
4-methylsulfonylphenylhydrazine hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The procedure of Example 9 was repeated using 1-(6-fluorobenzoxazol-2-yl)-4,4,4-trifluorobutane-1,3-dione and 4-methylsulfonylphenylhydrazine hydrochloride as the starting materials to obtain 6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-trifluoromethyl-1H-pyrazol-5-yl]benzoxazole.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06136831uspto-grants-2000_10