Reaktion #45579

Reaktionsgleichung

N-iodosuccinimide

acetic acid

4-bromo-3-fluoro-2-methoxy-5-methylaniline

→

4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

Lösungsmittel

brine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionfollowed by extraction twice with ethyl acetate
2. 2
   Waschenthe organic layer was washed three times with saturated brine
3. 3
   Trocknendried over anhydrous magnesium sulfate

Vorschrift

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

Quelle