Reaktion #45568

Reaktionsgleichung

triphosgene

2-amino-4-fluoro-5-iodo-3-methoxy-6-methylbenzoic acid

→

7-Fluoro-6-iodo-8-methoxy-5-methyl-1H-benzo[d][1,3]oxazine-2,4-dione

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Vorschrift

Under nitrogen atmosphere, triphosgene (1.5 g, 5.04 mmol) was added to a tetrahydrofuran (200 ml) solution of 2-amino-4-fluoro-5-iodo-3-methoxy-6-methylbenzoic acid (I-30) (4.1 g, 12.6 mmol), followed by stirring at 40° C. for 16 hours.

Quelle