Reaktion #45564

Reaktionsgleichung

1-fluoro-2-methoxy-5-methyl-3-nitrobenzene

→

compound

Ausbeute 81.2%

3-Fluoro-2-methoxy-5-methylaniline

Ausbeute 81.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtration and concentration under reduced pressure
2. 2
   Einengenthe eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure

Vorschrift

5% Palladium-carbon (wet, 100 mg) was added to a methanol (5 ml) solution of 1-fluoro-2-methoxy-5-methyl-3-nitrobenzene (I-25) (250 mg, 1.35 mmol), followed by stirring under hydrogen atmosphere for 30 minutes. After filtration and concentration under reduced pressure, the resulting residue was subjected to column chromatography, and the eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure to obtain the entitled compound (170 mg, 81%) as a yellow oily substance.

Quelle