Reaktion #45535

Reaktionsgleichung

hydrochloric acid

fluorene

n-butyl lithium hexane

2-tert-butyl-6,6-diphenyl fulvene

→

aimed compound

(3-tert-butyl-cyclopentadienyl)(fluorenyl)diphenylmethane

Lösungsmittel

diethyl ether

diethyl ether

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 200 ml three-necked flask equipped with a magnetic stirrer chip and three-way cock
2. 2
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
3. 3
   Sonstigea reddish-orange solid was obtained
4. 4
   SonstigeTo the solid, a solution prepared
5. 5
   workup.ADDITIONwas added
6. 6
   workup.STIRRINGstirred
7. 7
   Temperaturunder reflux for 7 days
8. 8
   Sonstigeto separate an organic phase
9. 9
   WaschenThe organic phase was washed with water and saturated brine
10. 10
    TrocknenThe organic phase was dried with anhydrous magnesium sulfate
11. 11
    Filtrationthe drying agent was filtered off
12. 12
    workup.DISTILLATIONThe solvent was distilled off under reduced pressure from the filtrate
13. 13
    Sonstigeorange brown oil was obtained
14. 14
    SonstigeThe oil was re-crystallized

Vorschrift

In a 200 ml three-necked flask equipped with a magnetic stirrer chip and three-way cock thoroughly purged with nitrogen, 0.76 g of fluorene (4.57 mmol) was dissolved in 40 ml of dehydrated diethyl ether in a nitrogen atmosphere. To the solution, 3.1 ml of a n-butyl lithium/hexane solution (1.57M: 4.87 mmol) was gradually added dropwise in an ice bath and stirred at room temperature for over night. The solvent was distilled off under reduced pressure and thereby a reddish-orange solid was obtained. To the solid, a solution prepared by dissolving 2.40 g of 2-tert-butyl-6,6-diphenyl fulvene (8.38 mmol) in 150 ml of dehydrated diethyl ether was added and stirred under reflux for 7 days. The reaction mixture was added to 150 ml of a hydrochloric acid aqueous solution (2%) and then diethyl ether was added therein to separate an organic phase. The organic phase was washed with water and saturated brine. The organic phase was dried with anhydrous magnesium sulfate and the drying agent was filtered off. The solvent was distilled off under reduced pressure from the filtrate and thereby orange brown oil was obtained. The oil was re-crystallized using hexane and thereby the aimed compound was obtained in an amount of 1.03 g (2.28 mmol) as a pale yellow solid. The solid further was purified with a chromatography using 100 g of silica gel (developing solvent: n-hexane) and the developing solvent was distilled off under reduced pressure and thereby the aimed compound was obtained in an amount of 0.370 g (0.817 mmol) as a yellow solid (yield: 67%).

Quelle