Reaktion #454965

ord-c80851c9d3c141bdbc008773279f234b

Reaktionsgleichung

N#Cc1cnccn1
2-cyanopyrazine
CCOC(=O)c1cc([N+](=O)[O-])sc1N
2-amino-5-nitro-3-ethoxycarbonyl-thiophene
O=P(Cl)(Cl)Cl
POCl3
→
O=[N+]([O-])c1cc2c(Cl)nc(-c3cnccn3)nc2s1
4-chloro-2-(pyrazin-2-yl)-6-nitro-thieno-[2,3-d]-pyrimidine

Edukte

N#Cc1cnccn1
2-cyanopyrazine
CCOC(=O)c1cc([N+](=O)[O-])sc1N
2-amino-5-nitro-3-ethoxycarbonyl-thiophene
O=P(Cl)(Cl)Cl
POCl3

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

With the procedure of Example 477, the reaction of 2-cyanopyrazine and 2-amino-5-nitro-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyrazin-2-yl)-6-nitro-thieno-[2,3-d]-pyrimidine

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06133271uspto-grants-2000_10