Reaktion #454962

Reaktionsgleichung

2-cyanopyrazine

2-amino-4-methyl-3-ethoxycarbonyl-thiophene

POCl3

→

4-chloro-2-(pyrazin-2-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

Reaktionsbedingungen

Vorschrift

With the procedure of Example 477, the reaction of 2-cyanopyrazine and 2-amino-4-methyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyrazin-2-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

Quelle