Reaktion #4549

Reaktionsgleichung

(s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-4,6-dichloro-pyrimidine

magnesium oxide

ethanol

→

(s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-pyrimidine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeinto a 200 ml flask, then add hydrogen under oil bath conditions at 50° C., until the logical amount of hydrogen has been absorbed
2. 2
   FiltrationThe catalyst is filtered
3. 3
   Sonstigeseparated
4. 4
   Extraktionether is extracted
5. 5
   WaschenAfter the ether layer is washed with water and with saturated salt water
6. 6
   Sonstigedried
7. 7
   Sonstigethe ether is evaporated

Vorschrift

Pour 1.88 g of optically active (s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-4,6-dichloro-pyrimidine, 0.4 g of 10% palladium-carbon, 0.55 g of magnesium oxide, 60 ml of ethanol, and 45 ml of water, into a 200 ml flask, then add hydrogen under oil bath conditions at 50° C., until the logical amount of hydrogen has been absorbed. The catalyst is filtered and separated, then ether is extracted. After the ether layer is washed with water and with saturated salt water, and dried, the ether is evaporated. The resultant impure product is repeatedly refined, and 0.9 g of optically active (s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-pyrimidine is obtained.

Quelle