Reaktion #454722

ord-3ca222c0f15245fc9c767bc021f5578c

Reaktionsgleichung

c1c[nH]cn1
imidazole
O=[N+]([O-])c1cccc(CNc2nc(Cl)nc3sc(C(F)(F)F)cc23)c1
2-chloro-6-trifluoromethyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine
→
O=[N+]([O-])c1cccc(CNc2nc(-n3ccnc3)nc3sc(C(F)(F)F)cc23)c1
2-(imidazol-1-yl)-6-trifluoromethyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine

Edukte

c1c[nH]cn1
imidazole
O=[N+]([O-])c1cccc(CNc2nc(Cl)nc3sc(C(F)(F)F)cc23)c1
2-chloro-6-trifluoromethyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure of Example 97, the reaction of imidazole with 2-chloro-6-trifluoromethyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine gives 2-(imidazol-1-yl)-6-trifluoromethyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06133271uspto-grants-2000_10